Resident Evil 4 Remake Best Weapons [Top 14]

Equip Leon with the best guns in Resident Evil 4 to survive the Ganados plague & save Ashley!

Resident Evil 4 Remake is packed with some of the best weapons from the series. You have the option of selecting the best guns out of 29 firearms in the game, which speaks volumes about how much versatility you can add to combat. While not all guns perform equally, and every weapon comes with a set of pros and cons, learning about the best ones is the key to survival in ganados plague.

Key Takeaways
  • Resident Evil 4 Remake features 29 Weapons for players to unlock.
  • If you acquire all weapons in RE4 Remake, you will unlock the Gun Fanatic trophy/achievement.

Here are the Best Weapons in RE4 Remake:

  • Red9: Powerful handgun; use the stock attachment for better accuracy and recoil
  • Punisher: Weak in power but has penetration power, great for crowd control
  • Matilda: Quick rate of fire, large capacity, best used with a stock, expensive upgrades
  • W-870: Remarkable stopping power, doubles in power with Exclusive upgrade
  • Killer7 Magnum: Powerful magnum weapon, limited ammo capacity
  • Bolt Thrower: Explosive bolts, remarkable accuracy, great for larger adversaries
  • Fighting Knife: Great for close-range combat and smashing boxes and barrels
  • Riot Gun Shotgun: powerful, high fire rate, effective against groups and tough enemies.
  • Striker Shotgun: high fire rate, large ammo capacity, tight spread, effective against groups and tough enemies, unique upgrade system.
  • Chicago Sweeper machine gun: high fire rate, large ammo capacity, superior damage output, and piercing capabilities, ideal for tough enemies.
  • LE5 Rifle: pinpoint precision, devastating stopping force, useful for long-range killing.
  • CQBR Assault Rifle: rapid rate of fire, good accuracy, enormous ammunition capacity, effective at close and medium range.
  • Stingray Sniper Rifle: fast firing speed, excellent rate of fire, pinpoint accuracy, effective against weak points.
  • Infinite Rocket Launcher: overkill version of the base rocket launcher, can one-shot most enemies and beat bosses easily.


Ammo Capacity16
Reload Speed1.25
Rate of Fire1.26

The Red9 handgun has undoubtedly earned its reputation as one of the Resident Evil 4 Remake’s best weapons. Its unrivaled power, surpassing all other non-magnum handguns, is a testament to its supremacy. Upon acquiring the Red9 in the Resident Evil 4 Remake, players may initially be put off by its unwieldy recoil and lackluster accuracy.

  • However, these shortcomings can be overcome by investing in indispensable stock attachments.
  • This upgrade transforms the Red9 into a formidable weapon, justifying the price and inventory space it requires.
  • Keep in mind, though, that the stock isn’t immediately available from the vendor, so persistence and patience are key to unlocking the full potential of this powerhouse handgun.

How To Get

During Chapter 4, you’ll find yourself at the Lake section, and here’s where the Red9 lies hidden.

  • Hop onto the boat and make your way to the shipwreck located at the lake’s center.
  • Once on the ship, you’ll encounter barrels and a cabin with a chest containing a gemstone.
  • To find the Red9, exit the cabin, veer to the right, and proceed towards the front of the ship.
  • A lavishly adorned chest holding the coveted Red9 awaits you just beyond the cabin.
  • In case you don’t manage to secure the Red9 during Chapter 4, fret not, as the merchant begins offering it for sale in Chapter 5.
  • After successfully rescuing Ashley from the church, head to Village Square, where the merchant’s stall is beside the Town Hall.
  • There, you’ll have the opportunity to purchase the powerful Red9 handgun.


Ammo Capacity24
Reload Speed1.50
Rate of Fire1.91

The Punisher handgun holds its own in the remake, despite some shortcomings. While the SG-09 R may boast slightly better stats and raw damage, the Punisher’s true value lies in its penetration power, allowing players to eliminate multiple enemies with a single shot if they’re properly aligned.

  • This distinctive feature is further enhanced by the Exclusive upgrade, which increases penetration 5x, making the Punisher an indispensable crowd-clearing weapon.
  • Complemented by a relatively low upgrade cost, swift firing rate, and rapid reload time.
  • The Punisher’s 9mm semi-automatic design offers a unique advantage in the arsenal of Resident Evil 4 Remake handguns, even though it may not pack the most powerful punch.

How To Get

  • You’ll have your first chance to get your hands on this unique weapon during Chapter 2.
  • Upon encountering the Merchant for the first time in the Trade section, you’ll learn that the Punisher is available in exchange for 5 Spinels.
  • To acquire this impressive handgun, simply ensure you’ve collected the required number of Spinels and visit the Merchant’s Shop.
  • Trade your Spinels for the Punisher, and you’ll be well-armed for the challenges that lie ahead in the game.


Ammo Capacity70
Reload Speed0.93
Rate of Fire2.50

Next in our best re4 weapons, we have the Matilda. Paying homage to Resident Evil 2, the Matilda is a three-round burst pistol that bridges the gap between traditional handguns and SMGs. While its firepower ranks in the middle amongst its handgun counterparts, it boasts the quickest rate of fire, reload speed, and largest capacity.

  • These attributes are further enhanced when a stock is attached, transforming the Matilda into an even more efficient and deadly weapon.
  • However, it’s important to note that the Matilda comes with a hefty price tag for full upgrades.
  • Despite this, Matilda’s unique features and versatility make it a valuable asset in the hands of skilled players.

How To Get

  • You’ll have the opportunity to obtain Matilda weapon during Chapter 9, following the completion of the hedge maze.
  • To get your hands on the Matilda, you’ll need to visit the Merchant’s Shop, where it’s available as a trade option.
  • Gather a total of 10 Spinels throughout your gameplay, and then approach the Merchant to make the trade.
  • With Matilda in your possession, you’ll be well-equipped to face the perils that await you in the latter stages of Resident Evil 4.


Power10.1 x2
Ammo Capacity10
Reload Speed0.95
Rate of Fire0.85

W-870 is a powerful shotgun that shines when confronting hordes of ganados, chainsaw-wielding adversaries, or the formidable El Gigante. The weapon is known for its tight spread and remarkable stopping power, enabling players to dispatch enemies with ease.

  • While it may have the cheapest upgrades and lowest initial power of all shotguns, the Exclusive upgrade doubles its power, catapulting it to the top as the most potent shotgun in the game.
  • Players must adapt to its slower rate of fire and reload speed, but these minor drawbacks are a small price to pay for the unparalleled power the W-870 shotgun delivers.

How To Get

  • During the early stages of the game, in Chapter 1, you’ll find yourself exploring the first village.
  • Keep an eye out for a defendable house situated in Village Square, near a tall tower. Venture inside this house and make your way to the second floor.
  • There, hanging on a wall, you’ll discover the W-870 shotgun.
  • Should you miss the opportunity to grab it during your first visit, don’t worry – you can still collect it after the sequence has concluded.
  • The W-870 shotgun is not only an excellent weapon but also holds significant value.
  • It can be sold for 6,000 Pesetas and repurchased for 12,000 Pesetas if needed.


Ammo Capacity15
Reload Speed1.40
Rate of Fire1.16

Killer7 is a powerhouse magnum weapon that delivers devastating blows with each shot, swiftly eliminating adversaries with only a few well-aimed rounds. The Magnum’s immense firepower truly shines when facing more challenging opponents, such as the armored El Gigante and the daunting Krauser. Additionally, its piercing capabilities make it a prime choice for penetrating the tough exterior of specific enemies.

  • The limited ammo capacity may present a drawback.
  • The Killer7 Magnum’s unrivaled stopping power more than compensates for this minor shortcoming, solidifying its position as a formidable weapon in the game.

How To Get

  • You will have the opportunity to obtain this powerful weapon during Chapter 13.
  • Once you’ve successfully cleared the castle and taken a boat ride to the Wharf, you’ll find the Killer7 Magnum available for purchase at the Merchant’s Shop.
  • With a price tag of 77,700 Pesetas, this impressive firearm is an investment worth making.
  • Secure the Killer7 Magnum, and you’ll be well-prepared to tackle the challenging obstacles that lie ahead in Resident Evil 4.

Bolt Thrower

Bolt Thrower
Ammo Capacity10 x2
Reload Speed0.94
Rate of Fire0.85

The Bolt Thrower’s explosive bolts pack a powerful punch, inflicting significant damage and knockback to multiple enemies with a single shot. The weapon’s remarkable accuracy allows players to eliminate foes with pinpoint precision, even from a distance.

  • Its distinctive piercing capabilities make it an excellent choice for penetrating the robust exteriors of larger adversaries, such as the El Gigante or regenerators.
  • Furthermore, the Bolt Thrower is a silent weapon, enabling players to dispatch enemies without alerting others in the vicinity.
  • Although its reloading process is slow, the Bolt Thrower’s overall efficacy far outweighs this minor drawback, making it a valuable addition to any player’s arsenal.

How To Get

  • Bolt Thrower is a remarkable weapon that becomes available relatively early in the campaign, specifically in Chapter 2.
  • After escaping the Factory and just before reaching the Mountain Village, you’ll encounter the ever-helpful Merchant.
  • The Bolt Thrower can be found among his offerings for a mere 10,000 Pesetas, making it an affordable yet valuable addition to your arsenal.
  • Don’t hesitate to invest in this handy weapon to bolster your firepower and overcome the challenges that await you in Resident Evil 4.

Fighting Knife

Fighting Knife
Attack Speed1.00

There are more potent weapons than the Fighting Knife. Yet it’s a fantastic asset for any skilled player to have. Use the Fighting Knife in tandem with your other weapons to save bullets and provide devastating close-range damage to your foes.

  • The Plague-infected villagers and Ganados are no match for its lightning-fast assault speed and stunning abilities.
  • The Fighting Knife also has other uses beyond combat, as it can be used to smash boxes and barrels to get access to valuable objects and ammunition.

How To Get

  • You won’t be able to buy or find the Fighting Knife anywhere else in the game.
  • Instead, you’ll need to beat Krauser in Chapter 14 to get access to it.
  • After beating this boss, the player will get the Fighting Knife as a reward.

Riot Gun

Ammo Capacity12
Reload Speed0.97
Rate of Fire1.10

Riot Gun Shotgun in Resident Evil 4, is one of the most powerful shotguns. This weapon boasts an impressive fire rate and a wide spray, making it incredibly effective against groups of enemies. The Riot Gun Shotgun’s raw stopping power is particularly useful against tougher enemies like the chainsaw-wielding maniacs and the heavily armored Ganados.

  • Its ability to deal massive damage even at medium range is also a significant advantage.
  • The weapon is capable of taking out enemies before they can get too close.
  • The Riot Gun Shotgun’s only downside is its reload time, but skilled players can use this brief period to reposition themselves and avoid enemy attacks.

How To Get

  • This remarkable shotgun becomes available during Chapter 6, after you’ve completed the sequence in which you defend the house alongside Luis.
  • To acquire the Riot Gun, simply visit the Merchant’s Shop, where it is offered for sale at a price of 28,000 Pesetas.
  • Secure this powerful weapon to enhance your arsenal and prepare for the thrilling challenges that lie ahead in Resident Evil 4.


Ammo Capacity24 x2
Reload Speed0.62
Rate of Fire1.57

Striker shotgun boasts a high fire rate, large ammo capacity, and a tight spread, making it incredibly effective against both groups of enemies and tougher foes. The shotgun’s unique upgrade system, which allows players to increase its ammo capacity, makes it even more versatile and effective in combat.

  • Its ability to pierce through multiple enemies with each shot also makes it an excellent choice for taking on groups of enemies.
  • The Striker Shotgun’s only downside is its slow reload time.
  • But skilled players can use this brief period to avoid enemy attacks and reposition themselves for their next shot.

How To Get

  • During Chapter 10, you’ll have the chance to acquire this high-damage weapon.
  • After completing the castle sequence, where you play as Ashley, you’ll return to Leon and find that the Merchant’s inventory has been updated.
  • Among the new additions, you’ll discover the Striker shotgun, which can be purchased for 38,000 Pesetas.
  • Adding this formidable weapon to your arsenal will undoubtedly enhance your firepower and prepare you for the thrilling challenges that await you in Resident Evil 4.

Chicago Sweeper

Chicago Sweeper
Ammo Capacity70
Reload Speed0.93
Rate of Fire2.50

Chicago Sweeper machine gun boasts a high fire rate and a large ammo capacity, making it incredibly effective against groups of enemies and tough bosses. Its superior damage output and piercing capabilities are ideal for defeating the game’s more formidable enemies.

  • The gun’s only real drawback is its hefty price tag, but skilled players will find the investment more than worth it.
  • Its rapid-fire capabilities and overall effectiveness make it a favorite among experienced players, and its iconic design and history make it a must-have for any fan of the series.

How To Get

  • This Tommy gun is available as a reward for completing the main story with an A Rank in Professional mode.
  • First, complete the main game to unlock Professional mode.
  • Then, by achieving an A rank or higher in this mode, you’ll successfully complete the “Leon A. Kennedy” challenge.
  • Following this accomplishment, the Chicago Sweeper will become accessible for purchase in the Extra Content Shop for 1,000 CP.
  • With this powerful weapon in your arsenal, you’ll be well-equipped to tackle even the most challenging Resident Evil 4 scenarios.


LE 5
Ammo Capacity60
Reload Speed1.05
Rate of Fire2.50

LE 5 is perfect for the long-range killing because of its pinpoint precision and devastating stopping force. It is useful for clearing out large groups of adversaries or removing impediments in the player’s way since it can pierce through numerous foes and items at once.

  • The LE5’s superiority in combat is bolstered by its ability to be upgraded to improve its damage output and magazine size.
  • Despite its sluggish firing rate, the LE5 rifle is a great option for gamers that want a more tactical approach to fighting.

How To Get

  • You will have the opportunity to obtain this weapon during Chapter 13 in the Regenerador Facility Freezer.
  • To gain access to the room housing the LE5, you must first solve the Electronic Lock Terminal in the Freezer.
  • This power calibration puzzle, similar to the ones you’ve already encountered, will lead you to the Northern Freezer room within the chilling facility teeming with the spine-chilling Regeneradors.
  • Successfully completing the puzzle and navigating the area will grant you access to the powerful LE5, an essential addition to your arsenal in Resident Evil 4.

CQBR Assault Rifle

CQBR Assault Rifle
Ammo Capacity32
Reload Speed1.25
Rate of Fire2.50

The CQBR Assault Rifle is a strong and flexible weapon in Resident Evil 4, excelling at both close and medium range. This assault weapon is perfect for clearing out big groups of foes and doing heavy damage to bosses thanks to its rapid rate of fire, good accuracy, and enormous ammunition capacity.

  • The CQBR Assault Rifle is a fan favorite among seasoned players due to its power and adaptability.
  • Despite the fact that it’s sluggish reload time might be a detriment in some scenarios.

How To Get

  • CQBR is a formidable weapon that can be found in Chapter 10 in the South Castle Library.
  • While you may initially discover its location during Ashley’s segment, you’ll only be able to secure the CQBR Assault Rifle once you regain control of Leon.
  • With the Cubic Device in hand, make your way to the library and proceed to the same area where Ashley obtained the keys, keeping an eye out for the knights.
  • At the designated spot, use your Cubic Device to solve a quick puzzle by aligning the shapes with the one on the wall.
  • Successfully completing the puzzle will reveal a hidden wall panel, granting you access to the sought-after CQBR Assault Rifle.


Ammo Capacity18
Reload Speed1.18
Rate of Fire0.92

Stingray sniper rifle is one of the best weapons in re4 remake, and that shouldn’t be overlooked. While it may not be the most powerful sniper rifle in the game – the SR M1903 boasts twice the power with its exclusive upgrade – the Stingray more than makes up for it with its excellent rate of fire and precision.

  • Its fast firing speed allows players to take out enemies quickly without losing sight of their target, while its pinpoint accuracy ensures that every shot counts.
  • The Stingray’s 3x power against weak points bonus also makes it a highly effective tool for taking out tougher enemies with precision shots.
  • In short, if you’re looking for a high-quality sniper rifle in Resident Evil 4, the Stingray is an excellent choice that delivers on both power and precision.

How To Get

  • To acquire the Stingray sniper rifle in Resident Evil 4 Remake, players must first reach Chapter 7 of the game.
  • Once there, the weapon can be purchased from the Merchant’s Shop for a price of 30,000 Pesetas.
  • While this may seem like a hefty price tag, the Stingray’s powerful capabilities and unique upgrade system make it well worth the investment.

Infinite Rocket Launcher

Rocket Launcher

If you really want the best weapon in Resident Evil 4 Remake that can potentially one-shot most enemies and beat bosses easily, then Infinite Rocket Launcher is the way to go. This is an overkill version of the base rocket launcher that you unlock much earlier and easily in RE4 Remake. Still, if you just want to point and shoot enemies, this is the way to go. 

  • RPG can one-shot most enemies.
  • The infinite ammo version of Rocket Launcher can be used to clear NG+ very easily.

How To Get

  • In Resident Evil 4 Remake, the Infinite Rocket Launcher is unlocked after beating the game and beginning a New Game+.
  • As soon as you arrive, you may buy the weapon from the Merchant for a whopping 2 million Pesetas.
  • Although this may seem like an unattainable number, players may build up the cash they need by selling their current weapons to the first merchant, particularly their improved weapons, which fetch a premium price.
  • In addition, the “X% off Rocket Launcher” weapon charm may be used to get a discount on the Infinite Rocket Launcher if players manage to snag it from the shooting range.

Final Remarks

This brings us to the end of our Resident Evil 4 Remake Best Weapons guide, where we have listed the best handguns, shotguns, SMG, Rifles, knifes and more. What is your go-to weapon for crowd control and 1vs1 fights? Let us know more about it in the comments section below. Also, before you leave, consider reading our Resident Evil 4 Remake Review.

Was this article helpful?

Thanks! Do share your feedback with us. ⚡

How could we improve this post? Please Help us. ✍

Irfan Ansari

With four years of Video Game Journalism and Tremendous love for Gaming, Irfan loves chatting and writing everything about video games.

Related Articles